Knockdown of CBX2 inhibits hepatocellular carcinoma proliferation in vivo. (A) Knockdown of CBX2 decreases the tumor size. We cultivated stable transfected Huh7 cells (LV3-ctl, LV3-Si3, LV5-ctl, LV5-CBX2) and injected the cells into nude mice subcutaneously for 20 days. (B) H&E staining results prove four groups of tumors are malignant tumors.(C) Knockdown of CBX2 decreases the tumor volumes. Upregulation of CBX2 increases the tumor volumes. The data are presented as the mean ± SD of three independent experiments. (*P < 0.05, **P < 0.01). (D) Knockdown of CBX2 decreases the tumor weights. Upregulate of CBX2 increases the tumor weights. The data are presented as the mean ± SD of three independent experiments. (*P < 0.05, **P < 0.01).