Table 4.
Univariate and multivariate cox proportional hazards regression models for estimating overall survival (N = 60)
| Characteristics | HR | 95% CI | P |
|---|---|---|---|
| Univariate analysis | |||
| Overall survival | |||
| Age (< 60 y vs ≥ 60 y) | 0.488 | 0.192 to 1.238 | 0.131 |
| Gender (male vs female) | 1.043 | 0.429 to 2.538 | 0.924 |
| Smoking history (smoker vs nonsmoker) | 1.341 | 0.591 to 3.040 | 0.483 |
| Alcohol history (drinker vs nondrinker) | 1.038 | 0.439 to 2.451 | 0.932 |
| Tumor size (> 4 cm vs ≤ 4 cm) | 1.561 | 0.684 to 3.564 | 0.291 |
| Lymph node metastasis (pN1 to pN2 vs pN0) | 2.385 | 0.939 to 6.057 | 0.038 |
| TNM stage (III-IV vs I-II) | 2.631 | 0.971 to 7.130 | 0.017 |
| Pathological differentiation (Moderately to poorly vs Well) | 1.318 | 0.569 to 3.056 | 0.519 |
| Disease Site | 0.941 | 0.716 to 1.238 | 0.666 |
| Recurrence | 1.038 | 0.381 to 2.817 | 0.937 |
| miR-519d expression (high vs low) | 0.192 | 0.065 vs 0.564 | 0.003 |
| MMP3 expression (high vs low) | 2.615 | 1.104 to 6.193 | 0.029 |
| Multivariate analysis | |||
| Overall survival | |||
| Lymph node metastasis (pN1 to pN2 vs pN0) | 1.319 | 0.347 to 5.015 | 0.685 |
| TNM stage (III-IV vs I-II) | 1.172 | 0.330 to 4.167 | 0.806 |
| miR-519d expression (high vs low) | 0.215 | 0.058 to 0.805 | 0.023 |
| MMP3 expression (high vs low) | 1.403 | 0.430 to 4.581 | 0.575 |
Abbreviations: CI, confidence interval; HR, hazard ratio; T, tumor stage; pN, pathological lymph node status; TNM, tumor-lymph node-metastasis classification.