Table 1.
Relationship between PNI and clinicopathological characteristics of GISTs patients
| Factor | Total (n = 431) | PNI ≥ 47.45 (n = 279) | PNI < 47.45 (n = 152) | p value |
|---|---|---|---|---|
| Age [n (%)] | ||||
| < 65 | 323 (74.9) | 211 (75.6) | 112 (73.7)) | 0.656 |
| ≥ 65 | 108 (25.1) | 68(24.4) | 40 (26.3) | |
| Sex [n (%)] | ||||
| Male | 209 (48.5) | 123 (44.1) | 86 (56.6) | 0.013 |
| Female | 222 (51.5) | 156 (55.9) | 66 (43.4) | |
| Tumor site [n (%)] | ||||
| Stomach | 202 (46.9) | 153 (54.8) | 49 (32.2) | <0.001 |
| Intestine | 171 (39.7) | 80 (28.7) | 91 (59.9) | |
| Colorectum | 46 (10.7) | 38 (13.6) | 8 (5.3) | |
| E-GIST | 12 (2.8) | 8 (2.9) | 4 (2.6) | |
| Tumor size (cm) [n (%)] | ||||
| 0-2.0 | 67 (15.5) | 56 (20.1) | 11 (7.2) | 0.002 |
| 2.1-5.0 | 212 (49.2) | 134 (48.0) | 78 (51.3) | |
| 5.1-10.0 | 112 (26.0) | 69 (24.7) | 43 (28.3) | |
| >10 | 40(9.3) | 20 (7.2) | 20 (13.2) | |
| Mitotic index (per 50 HPF) [n (%)]* | ||||
| 0-5 | 344 (81.3) | 229 (83.6) | 115 (77.2) | 0.041 |
| 6-10 | 51 (12.1) | 33 (12.0) | 18 (12.1) | |
| >10 | 28 (6.6) | 16 (4.4) | 12 (10.7) | |
| Risk classification [n (%)]** | ||||
| Very low | 60 (14.0) | 49 (17.7) | 11 (7.2) | <0.001 |
| Low | 176 (41.0) | 112 (40.4) | 64 (42.1) | |
| Intermediate | 52 (12.1) | 43 (15.5) | 9 (5.9) | |
| High | 141 (32.9) | 73 (26.4) | 68 (44.7) | |
| Hemoglobin (g/L) | 122.51±26.24 | 98.18±24.72 | <0.001 | |
| Platelet (109/L) | 211.06±76.31 | 215.70±97.35 | 0.929 | |
| Neutrophil (109/L) | 3.43±1.25 | 4.10±2.03 | 0.006 |
HPF: high-power fields; E-GIST: extra-gastrointestinal stromal tumor; *: mitotic index (per 50 HPF) of 8 patients were not clear. **among the 8 patients with unclear mitotic index, 6 patients had clear risk classification based on tumor size, site and rupture status, while 2 patients had unclear risk classification.