Table 5.

Multivariate analysis of overall survival

Variables	HR (95%CI)	P value
Analysis with CD8 expression
CD8 change	0.73(0.55-0.97)	0.028
Gender
Male	1
Female	2.51(1.06-5.92)	0.036
Tumor differentiation
Poorly differentiated	1
Well or moderately differentiated	0.59(0.26-1.33)	0.203
Downstaging
Yes	1
No	1.18(0.49-2.87)	0.709
Tumor regression grading (Mandard system)
Grade 2 or 3	1
Grade 4	2.46(0.93-6.49)	0.070
Analysis with PD-1 expression
PD-1 change	0.76(0.60-0.97)	0.027
Gender
Male	1
Female	1.72(0.72-4.13)	0.224
Tumor differentiation
Poorly differentiated	1
Well or moderately differentiated	0.47(0.20-1.08)	0.075
Downstaging
Yes	1
No	1.14(0.47-2.74)	0.772
Tumor regression grading (Mandard system)
Grade 2 or 3	1
Grade 4	2.63(0.98-7.06)	0.054
Analysis with PD-L1 expression
PD-L1	0.67(0.45-0.98)	0.038
Gender
Male	1
Female	1.47(0.57-3.79)	0.429
Tumor differentiation
Poorly differentiated	1
Well or moderately differentiated	0.50(0.22-1.17)	0.109
Downstaging
Yes	1
No	1.30(0.56-3.01)	0.537
Tumor regression grading (Mandard system)
Grade 2 or 3	1
Grade 4	2.69(1.01-7.17)	0.048