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EV-TPP1-l treatment increased lifespan in LINCL mice. 1 week old LINCL mice were injected i.p. with EV-TPP1-l three times every week (crosses) or EVs alone (circles). Control LINCL mice (diamonds) and wild type animals (triangles) were injected with saline. A survival of treated animals was recoded over three months. A significantly greater lifespan (p < 0.05) was demonstrated in EV-TPP1-l treatment group compared to CLN2 mice treated with saline (N = 6).
