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. 2019 Jun 20;19:605. doi: 10.1186/s12885-019-5802-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — PD-L1 and IFN-γ signature genes are activated in MSI subtype colon cancer patients. a Box plots showed the PD-L1 (CD274) expression in 5 GEO datasets. P values showed the difference of PD-L1expressions between MSI and MSS colon cancer patients determined by Student’s t test. b Box plots showed the IFN-γ (IFNG) expression in 7 GEO datasets. c Un-supervised clustering heatmaps showed the IFN-γ signature genes in MSI and MSS colon cancer patients in GSE13294, GSE18088 and GSE39084 datasets