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. 2019 Jun 20;19:605. doi: 10.1186/s12885-019-5802-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — IFN-γ signature genes are associated with favorable outcomes in colon cancer. a Relationships of the MSI/MSS status and overall survival were analyzed from GSE39084. Kaplan Meier survival analysis was used to compare between MSI colon cancer patients and MSS colon cancer patients. Log-rank test estimated p value. b Relationships of the PD-L1, IRF1, IFN-γ and IFN-γ signature genes IDO1, HLA-DRA, CXCL9, CXCL10, STAT1 expressions and colon cancer relapse free or overall survival were analyzed from GSE39582 and GSE24551 datasets. Kaplan Meier survival analysis was used to compare colon cancer patients with high gene expression to patients with low genes expression. Log-rank test estimated p value. c Relationships of β-catenin (CTNNB1), TGFBR2 expression and colon cancer overall survival were analyzed