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. 2019 Jun 14;12:1703–1718. doi: 10.2147/IDR.S201124

Table 3.

MICs/MBCs (µg/mL) of norfloxacin, levofloxacin, and ciprofloxacin alone and in combination with CCCP or ketoconazole for the tested bacterial isolates

Strain Norfloxacin (MIC/MBC) (∆) Levofloxacin (MIC/MBC) (∆) Ciprofloxacin (MIC/MBC) (∆) Ethidium bromide (MIC/MBC) (∆)
S. aureus sensitive strain

  • ● Antibiotic alone

  • ● +CCCP

  • ● +ketoconazole

1/1
0.5/0.5
1/1

0.5/1
0.25/0.5
0.5/1

0.25/0.5
0.25/0.25
0.25/0.25

2/4
2/2
2/4
S. aureus ATCC6538

  • ● Antibiotic alone

  • ● +CCCP

  • ● +ketoconazole

16/32
1/1 (16)
1/1 (16)

16/32
0.25/0.5 (64)
0.25/0.25 (64)

64/64
0.25/0.5 (256)
0.25/0.5 (256)

512/1024
0.5/0.5 (1024)
0.5/0.5 (1024)
S. aureus R

  • ● Antibiotic alone

  • ● +CCCP

  • ● +ketoconazole
16/32
0.5/1 (32)
0.125/0.25 (128)
16/16
1/2 (16)
0.5/1 (32)
16/32
2/4 (8)
1/2 (16)
64/128
0.125/0.25 (512)
0.125/0.25 (512)
S. aureus 5ʹ

  • ● Antibiotic alone

  • ● +CCCP

  • ● +ketoconazole
16/32
8/16 (2)
2/4 (8)
16/32
8/16 (2)
2/2 (8)
16/32
2/4 (8)
0.5/1 (32)
8/16
4/8 (2)
0.25/0.5 (32)

Notes: (∆) MIC fold change between antibiotic alone and antibiotic+CCCP, ie ratio of MIC of antibiotic alone to that of antibiotic+CCCP.

Abbreviations: CCCP, carbonyl cyanide m-chlorophenylhydrazone; MBC, lowest concentration of antibacterial agent that reduces the viability of the initial bacterial inoculum by ≥99.9%; MIC, minimum inhibitory concentration; S. aureus, Staphylococcus aureus.