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. 2019 Jun 13;10:1376. doi: 10.3389/fimmu.2019.01376

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Copyright © 2019 Garcia-Castillo, Komatsu, Clua, Indo, Takagi, Salva, Islam, Alvarez, Takahashi, Garcia-Cancino, Kitazawa and Villena.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Lactobacillus fermentum UCO-979C and L. fermentum CRL973 on intestinal and serum cytokines of adult immunocompetent mice after lipopolysaccharide (LPS) challenge. L. fermentum UCO-979C or CRL973 were administered to different groups of mice for 2 consecutive days at a dose of 10⁸ cells/mouse/day. Untreated mice were used as controls. Lactobacilli-treated and control mice were challenged with LPS by intraperitoneal injection. One day after the challenge, the concentrations of TNF-α, IFN-γ, and IL-10 in intestinal fluid and serum were determined by ELISA. The results represent three independent experiments. Results are expressed as mean ± SD. Significantly different from control mice *(P < 0.05).