FIG. 2.

Simulated time course of sertraline plasma concentrations in adolescents. In the standard dosing model (A), treatment was initiated at 50 mg daily and increased by 50 mg daily during the first 4 weeks of treatment, as described in the Pediatric OCD Treatment Study (POTS) (March et al. 1998). In the pharmacogenetically guided dosing model (B), sertraline was titrated as described in the text to mirror the sertraline exposure of an adolescent who is a NM. Finally, for NMs, RMs, and UMs, bis in die (b.i.d.) dosing regimens were modeled (C). Color images are available online.