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. 2019 Jun 19;15:1744806919857297. doi: 10.1177/1744806919857297

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Effect of EGFR inhibitor gefitinib on CCD-induced nociceptive hypersensitivities. Single injection of gefitinib intraperitoneally (i.p., a) or intrathecally (i.t., b) dose dependently reversed the decrease in PWTs to mechanical stimulation. All rats were performed CCD surgery. N = 7 or 8 rats/group. Two-way RM ANOVA (effect vs. group × time interaction) followed by post hoc Tukey test, ***P < 0.001 versus baseline value before CCD surgery. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, versus the corresponding time point in the vehicle (Veh, 20% DMSO) group or versus the value before drug administration. I.t. injection of gefitinib (once daily for 7 days) dose dependently blocked the decrease of PWTs to mechanical stimulation (c), PWLs to thermal stimulation (d), or positive response latencies to cold stimulation (e) on the ipsilateral side of CCD rats. The first injection starts at 30 min before CCD surgery. N = 6 rats/group. Two-way RM ANOVA (effect vs. group × time interaction) followed by post hoc Tukey test, ***P < 0.001 versus the corresponding time point in the sham + Veh group. ^#P < 0.05, ^###P < 0.001 versus the corresponding time point in the CCD + Veh group. CCD: chronic compression of dorsal root ganglion; i.p.: intraperitoneal; i.t.: intrathecal; PWL: paw withdrawal latency; PWT: paw withdrawal threshold.