Table 2.
Classical HLA allele associations
| Autoantibody | Number of cases | SNP2HLA classical HLA association | |||
| Gene | Allele | P value | OR (95% CI) | ||
| Jo-1 | 332 | HLA-B | 08:01 | 2.28×10–53 | 3.37 (2.37 to 4.83) |
| HLA-DRB1 | 03:01 | 3.25×10–9 | 3.09 (2.08 to 4.30) | ||
| TIF1 | 197 | HLA-DQB1 | 02 | 2.34×10–10 | 2.49 (1.88 to 3.31) |
| PM/Scl | 136 | HLA-DQB1 | 02:01 | 1.47×10–26 | 17.50 (10.63 to 30.59) |
| Mi-2 | 104 | HLA-DRB1 | 07:01 | 4.92×10–13 | 5.47 (3.48 to 8.77) |
| cN1A | 64 | HLA-DRB1 | 03:01 | 1.40×10–11 | 9.23 (4.95 to 18.01) |
| HMGCR | 52 | HLA-DRB1 | 11 | 5.09×10–6 | 4.92 (2.52 to 9.97) |
4-digit alleles are preferentially reported unless a 2-digit allele is significantly more associated. P values (uncorrected), OR and 95% CI were calculated in a regression including the most significantly associated independent variants. Associations reaching study-wide significance are reported (p<2.9×10–5).
HLA, human leucocyte antigen.