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Schematic diagram of the study design. Eighteen healthy volunteers randomised 2:1 to receive LPS or saline and 20 patients with stable COPD (stage 2/3) completed the protocol. Ten patients with COPD were scanned 7–10 days later to determine reproducibility. 99mTc, 99mTechnetium; HVs, healthy volunteers; LPS, lipopolysaccharide; SPECT, single-photon emission CT.
