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Serial cross-sectional associations of estimated SD change in SHBG, bioavailable testosterone (BT) or total testosterone (TT), per copy of SHBG-raising allele for nine genetic variants used as SHBG instrumental variables (IV) in the Mendelian randomisation (MR) analyses. Associations assessed in a subset of Avon Longitudinal Study of Parents and Children (ALSPAC) males across five available time points. SHBG, sex hormone-binding globulin.
