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. 2019 Apr 1;74(7):633–642. doi: 10.1136/thoraxjnl-2018-212207

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Forest plots of the individual instrumental variable (IV) effects in the male subsample of UK Biobank using the two combinations of IVs to assess the genetic effect of sex hormone-binding globulin (SHBG) on asthma. Mendelian randomisation (MR) effect sizes are presented as log odds for asthma per unit increase in log SHBG. Methods used include the weighted-median (All-WM), MR Egger regression (All-MR Egger) and inverse-variance weighted (All-IVW). (A) IV combination A includes nine single nucleotide polymorphisms (SNP) and (B) IV combination B includes three SNPs located in the SHBG gene.