Table 2.
Results of serial cross-sectional analysis of SHBG, TT or BT on asthma (using multiple imputation) adjusted for previous measures of asthma and sex hormones (where available) at five time points in a subsample of 512 males in ALSPAC
| Age at sex hormone exposure (years) | Age at asthma outcome (years) | OR* (95% CI) SHBG | n with data for SHBG (% missing)† | OR* (95% CI) total testosterone | n with data for total testosterone (% missing)† | OR* (95% CI) bioavailable testosterone | n with data for bioavailable testosterone (% missing) | n after multiple imputation |
| 9.9 | 10.7 | 0.96 (0.74 to 1.24) | 381 (26) | 1.12 (0.87 to 1.43) | 381 (26) | 1.02 (0.77 to 1.34) | 381 (26) | 512 |
| 11.8 | 13.1 | 1.54 (0.71 to 3.37) | 339 (34) | 0.85 (0.55 to 1.32) | 338 (34) | 0.79 (0.47 to 1.34) | 338 (34) | 512 |
| 13.8 | 13.8 | 1.32 (0.64 to 2.70) | 318 (38) | 0.80 (0.46 to 1.38) | 315 (38) | 0.86 (0.48 to 1.55) | 315 (38) | 512 |
| 15.5 | 16.5 | 1.18 (0.67 to 2.06) | 263 (49) | 0.89 (0.59 to 1.35) | 262 (49) | 0.87 (0.56 to 1.35) | 262 (49) | 512 |
| 17.8 | 22.9 | 1.02 (0.57 to 1.83) | 144 (72) | 0.71 (0.43 to 1.16) | 99 (81) | 0.87 (0.54 to 1.41) | 99 (81) | 512 |
*OR for asthma per SD increase in either SHBG, TT or BT.
†n refers to the number of individuals with complete data in the analysis of specified hormone (before multiple imputation). Per cent missing refers to the fraction of individuals missing some data (either asthma measurements, hormone measurements or covariates, where covariates include any previous measurement of asthma and hormone) at each time point, which were subject to multiple imputation.
ALSPAC, Avon Longitudinal Study of Parents and Children; BT, bioavailable testosterone; SHBG, sex hormone-binding globulin; TT, total testosterone.