Table 1.

Overview of Medicines Available for Use in PAH for Adults and Children

Class of Products	Product	Authorization for Adults			Authorization for Children
		EU	United States	Canada	EU	United States	Canada
Prostacyclin analogue	Treprostinil	No	Yes	Yes	No	No	No
	Selexipag	Yes	Yes	Yes	No	No	No
	Treprostinil diethanolamine	No	Yes	No	No	No	No
	Iloprost	Yes	Yes	No	No	No	No
	Epoprostenol	Yes	Yes	Yes	No	No	No
Endothelin receptors Antagonist	Bosentan	Yes	Yes	Yes	Pharmacokinetics data	Yes	Pharmacokinetics data
	Ambrisentan	Yes	Yes	Yes	No	No	No
	Macitentan	Yes	Yes	Yes	No	No	No
Phosphodiesterase type 5 inhibitor	Sildenafil	Yes	Yes	Yes	Yes	No	No
	Tadalafil	Yes	Yes	Yes	No	No	No
Guanylate cyclase stimulators	Riociguat	Yes	Yes	Yes	No	No	No

Pediatric indications have not been granted; however, results of pharmacokinetic studies in the different pediatric age groups are summarized in the Summary of Product Characteristics, with a comparison to adults. Uncertainties caused by limited experience are also stated. EU indicates European Union; PAH, pulmonary arterial hypertension.