Table 2.
Association Between Different Time Intervals and 90‐Day Good Outcome (mRS 0‐2)
| Time Interval (Percentiles), min | OR (95% CI)a | P Value | |||
|---|---|---|---|---|---|
| <33rd | 33rd to 66th | >66th | |||
| Onset to reperfusion, min | 247 (190‐270)b | 368 (329‐405)b | 560 (491‐707)b | ||
| n (%) | 15/31 (48.4) | 13/32 (40.6) | 10/32 (31.3) | 0.16c | |
| Unadjusted OR (95% CI) | 1.00 (reference) | 0.73 (0.26‐1.98) | 0.48 (0.17‐1.36) | 0.96 (0.90‐1.02) | 0.23 |
| Adjusted OR (95% CI)d | 1.00 (reference) | 0.53 (0.14‐1.94) | 0.26 (0.05‐1.05) | 0.93 (0.85‐1.01) | 0.074 |
| Onset to imaging, min | 82 (65‐103)b | 137 (123‐147)b | 270 (231‐389)b | ||
| n (%) | 13/29 (44.8) | 12/30 (40.0) | 9/29 (31.0) | 0.28c | |
| Unadjusted OR (95% CI) | 1.00 (reference) | 0.82 (0.29‐2.31) | 0.55 (0.18‐1.62) | 0.96 (0.88‐1.05) | 0.35 |
| Adjusted OR (95% CI)d | 1.00 (reference) | 0.47 (0.12‐1.82) | 0.37 (0.09‐1.53) | 0.91 (0.81‐1.02) | 0.11 |
| Imaging to groin puncture, min | 73 (39‐89) | 142 (127‐153) | 225 (192‐302) | ||
| n (%) | 10/29 (34.5) | 13/30 (43.3) | 11/29 (37.9) | 0.79c | |
| Unadjusted OR (95% CI) | 1.00 (reference) | 1.45 (0.50‐4.17) | 1.16 (0.39‐3.40) | 1.02 (0.89‐1.16) | 0.82 |
| Adjusted OR (95% CI)d | 1.00 (reference) | 0.88 (0.22‐3.54) | 0.87 (0.22‐3.37) | 0.99 (0.85‐1.17) | 0.97 |
| Imaging to reperfusion, min | 126 (100 to 144)b | 204 (180‐217)b | 314 (277‐402)b | ||
| n (%) | 13/29 (44.8) | 11/30 (36.7) | 10/29 (34.5) | 0.42c | |
| Unadjusted OR (95% CI) | 1.00 (reference) | 0.71 (0.25‐2.02) | 0.65 (0.22‐1.87) | 0.96 (0.86‐1.07) | 0.49 |
| Adjusted OR (95% CI) d | 1.00 (reference) | 0.46 (0.11‐1.85) | 0.39 (0.09‐1.56) | 0.93 (0.80‐1.08) | 0.34 |
IQR indicates interquartile range; mRS, modified Rankin Scale; mTICI, modified Treatment In Cerebral Infarction; NIHSS, National Institute of Health Stroke score; OR, odds ratio.
a
Odds ratio calculated per 30‐min increase.
b
Median (IQR) of time interval.
c
Calculated using Cochran‐Armitage trend test.
d
Prespecified adjustment for reperfusion grade (mTICI 2b vs 3), age, and baseline NIHSS score.