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. 2019 Jun 1;8(11):e011431. doi: 10.1161/JAHA.118.011431

Figure 5.

Figure 5

Insulin‐mediated activation of eNOS (endothelial NO synthase) and AKT (protein Kinase B) in response to siRNA‐mediated knockdown of FSP27 in the subcutaneous depot. A, Representative immunoblot demonstrating insulin‐mediated activation of eNOS and AKT in subcutaneous fat under scrambled siRNA (small interfering RNA) conditions and after knockdown of FSP27 by siRNA. B, Quantification of percent change in insulin‐mediated activation of eNOS at baseline and after siRNA‐mediated knockdown of FSP27 in the subcutaneous fat depot. C, Quantification of percent change in insulin‐mediated activation of AKT at baseline and after siRNA‐mediated knockdown of FSP27 in subcutaneous fat depot (n=10, P<0.05). Data are presented as arbitrary units and as mean±SEM. FSP27 indicates fat‐specific protein 27. *indicates statistical significance, such as P < 0.05.