Table 3.
Baseline Echocardiogram Measurements in Mice With Early Hypertrophy
| OGTKO | Control | ||
|---|---|---|---|
| Pre‐Tam (n=17) | Pre‐Op (n=25) | Pre‐Op (n=27) | |
| HR, bpm | 454±8 | 453±8 | 441±5 |
| EDD, mm | 4.2±0.1 | 4.4±0.1 | 4.3±0.1 |
| ESD, mm | 3.4±0.1 | 3.4±0.1 | 3.3±0.1 |
| LVPWd, mm | 0.70±0.02 | 0.72±0.02 | 0.72±0.02 |
| FS, % | 20.7±0.6 | 22.6±0.8 | 23.0±0.7 |
| EF, % | 42.3±1.1 | 45.4±1.4 | 46.2±1.1 |
Values are expressed as mean±standard error of the mean. Baseline echocardiograms were performed before surgery. Mice are grouped and evaluated according to their genotypes. O‐linked β‐N‐acetylglucosamine transferase knockout (OGTKO) mice had echocardiograms immediately before starting 4‐hydroxytamoxifen injections (Pre‐Tam). Preoperative (Pre‐Op) measurements were performed after the 5‐day Tam washout period in both genotypes. Control mice did not have Pre‐Tam echocardiograms. P>0.05 via unpaired t test for all measurements between control Pre‐Op vs OGTKO Pre‐Op. P>0.05 via unpaired t test for all measurements between OGTKO Pre‐Tam vs OGTKO Pre‐Op. In OGTKO mice with echocardiograms at both Pre‐Tam and Pre‐Op (n=17), P>0.05 for all measurements via a paired t test (values not shown separately from the entire cohort). bpm indicates beats per minute; EDD, left ventricular end‐diastolic diameter; EF, left ventricular ejection fraction; ESD, left ventricular end‐systolic diameter; FS, left ventricular fractional shortening; HR, heart rate; LVPWd, left ventricular posterior wall thickness in diastole.