Table 6.
Echocardiogram Measurements in the Established Hypertrophy Groups Before Starting 4‐Hydroxytamoxifen (Pre‐Tam) and at Experimental End (End)
| Sham | TAC | |||||||
|---|---|---|---|---|---|---|---|---|
| Pre‐Tam | End | Pre‐Tam | End | |||||
| Control (n=14) | OGTKO (n=11) | Control (n=14) | OGTKO (n=11) | Control (n=19) | OGTKO (n=16) | Control (n=19) | OGTKO (n=16) | |
| HR, bpm | 460±9 | 451±15 | 470±10 | 512±9 | 503±7* | 490±11 | 538±12† | 525±16 |
| TAC velocity, m/s | N/A | N/A | N/A | N/A | 4.4±0.1 | 4.4±0.1 | ND | ND |
| EDD, mm | 4.3±0.0 | 4.4±0.1 | 4.3±0.1 | 4.7±0.1‡ | 4.3±0.1 | 4.1±0.1 | 4.4±0.1 | 5.0±0.1§ |
| ESD, mm | 3.3±0.1 | 3.4±0.1 | 3.2±0.1 | 3.9±0.1‡ | 3.3±0.1 | 3.1±0.1 | 3.4±.01 | 4.5±0.2§ , ∥ |
| LVPWd, mm | 0.81±0.02 | 0.82±0.03 | 0.83±0.03 | 0.87±0.04 | 0.94±0.03* | 0.99±0.02¶ | 0.99±0.03† | 0.93±0.03 |
| FS, % | 22.8±1.1 | 21.9±1.1 | 23.8±0.9 | 17.7±0.7‡ | 22.4±1.0 | 24.2±1.1 | 21.6±1.0 | 10.4±1.0§ , ∥ |
| EF, % | 45.0±2.1 | 44.4±1.9 | 47.6±1.5 | 36.9±1.3‡ | 45.1±1.7 | 48.4±1.9 | 43.8±1.8 | 22.4±2.1§ , ∥ |
Values are expressed as mean±standard error of the mean. For Pre‐Tam heart rate (HR) in O‐linked β‐N‐acetylglucosamine transferase knockout (OGTKO) sham vs OGTKO transverse aortic constriction (TAC), P=0.073. bpm indicates beats per minute; EDD, left ventricular end‐diastolic diameter; EF, left ventricular ejection fraction; ESD, left ventricular end‐systolic diameter; FS, left ventricular fractional shortening; LVPWd, left ventricular posterior wall thickness in diastole; N/A, not applicable; ND, not done.
*P<0.05 Pre‐Tam control sham vs Pre‐Tam control TAC; † P<0.05 End control sham vs End control TAC; ‡ P<0.05 End control sham vs End OGTKO sham; § P<0.05 End control TAC vs End OGTKO TAC; ∥ P<0.05 End OKGTO sham vs End OGTKO TAC; ¶ P<0.05 Pre‐Tam OGTKO sham vs Pre‐Tam OGTKO TAC.