Table 4.
Association Between BP Category and the Development of CVD by CVD Risk Stratification, on the Basis of Different Risk Scores
| BP Categories | ASCVD Risk Score, %a | Framingham Risk Score, %a | ||
|---|---|---|---|---|
| <10 | ≥10 | <10 | ≥10 | |
| No history of hypertension | ||||
| SBP <120 mm Hg and DBP <80 mm Hg | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| SBP 120–129 mm Hg and DBP <80 mm Hg | 1.47 (1.15–1.87) | 1.10 (0.62–1.95) | 1.53 (1.16–2.01) | 1.12 (0.77–1.65) |
| SBP 130–139 mm Hg or DBP 80–89 mm Hg | 1.59 (1.34–1.88) | 0.89 (0.57–1.38) | 1.74 (1.44–2.11) | 0.96 (0.73–1.26) |
| SBP ≥140 mm Hg or DBP ≥90 mm Hg | 2.16 (1.70–2.75) | 1.47 (0.92–2.37) | 1.91 (1.97–2.66) | 1.67 (1.24–2.25) |
| History of hypertension | ||||
| With antihypertensive medication | ||||
| SBP <130 mm Hg and DBP <80 mm Hg | 1.46 (1.08–1.97) | 1.06 (0.63–1.78) | 1.66 (1.13–2.44) | 1.03 (0.72–1.46) |
| SBP 130–139 mm Hg and DBP 80–89 mm Hg | 1.75 (1.21–2.52) | 1.81 (1.10–2.96) | 2.54 (1.53–4.22) | 1.44 (1.00–2.06) |
| SBP ≥140 mm Hg or DBP ≥90 mm Hg | 1.90 (1.01–3.59) | 1.41 (0.68–2.94) | 0.78 (0.11–5.53) | 1.60 (0.96–2.65) |
| Without antihypertensive medication | 1.95 (1.46–2.62) | 1.71 (1.03–2.83) | 1.85 (1.26–2.70) | 1.73 (1.22–2.44) |
P=0.208 for the overall interaction between ASCVD risk strata (<10% vs ≥10%) and BP categories for development of CVD all event (adjusted model); P<0.001 for the overall interaction between Framingham risk score strata (<10% vs ≥10%) and BP categories for development of CVD all event (adjusted model). Incidence density (per 10 000 person‐years): 12.8 for subjects with ASCVD risk <10% and 102.7 for subjects with ASCVD risk ≥10%; 10.1 for subjects with Framingham risk score <10% and 66.7 for subjects with Framingham risk score ≥10 %. ASCVD risk score was based on the Pooled Cohorts Equation. ASCVD indicates atherosclerotic CVD; BP, blood pressure; CVD, cardiovascular disease; DBP, diastolic BP; SBP, systolic BP.
Multivariable‐adjusted hazard ratios (95% CIs) were estimated from Cox proportional hazard model. Multivariable model 1 was adjusted for age, sex, center, year of screening examination, body mass index, smoking status, alcohol intake, physical activity, educational level, total calorie intake, history of diabetes mellitus, statin medication, Charlson comorbidity index, and sodium intake.