Figure 3.

Branched‐chain α‐ketoacid dehydrogenase kinase (BCKDK) inhibitory treatment improved myocardium contractility and wall motion. Mice were subjected to transverse aortic constriction (TAC) procedure for 2 weeks and then were randomized to be treated with BT2 (n=9) or vehicle (n=8) for an additional 6 weeks. Relative global longitudinal strain (GLS; A), global radial strain (GRS; B), and respective global strain rate (GLSR and GRSR; C and D) for both groups at indicated time points were presented. Means of systolic velocity (E and F) and displacement (G and H) at longitudinal and radial planes were presented. Two‐way ANOVA, followed by Bonferroni's post hoc test, was performed to evaluate the differences between groups over the treatment period (from week 4 to week 8). Data were presented as mean±SEM. *P<0.05.