Table 3.
Association of Antidepressant Medication Type With Incident CVD in the ARIC Cohort Study, by Censoring Subjects Who Stopped or Changed Antidepressant Medication Type During Any of the Visits and While Considering Antidepressant Reports as a Time‐Dependent Exposure
| Outcomes | ||||
|---|---|---|---|---|
| AF | HF | MI | Ischemic Stroke | |
| No. of events, time‐adjusted | 212 | 250 | 117 | 82 |
| Median follow‐up, y | 5.1 | 5.1 | 5.1 | 5.1 |
| No. of events, time dependent | 231 | 276 | 140 | 100 |
| Median follow‐up, y | 5.2 | 5.2 | 5.2 | 5.4 |
| HR (95% CI)a | ||||
|---|---|---|---|---|
| Censored analysis | 1.22 (0.89–1.66) | 0.96 (0.72–1.28) | 0.95 (0.62–1.44) | 1.14 (0.70–1.88) |
| Time‐dependent analysis | 1.20 (0.91–1.59) | 1.04 (0.81–1.35) | 1.13 (0.78–1.64) | 1.04 (0.67–1.62) |
Censored analysis: Censoring subjects when they stop using or change antidepressant type. Time‐dependent analysis: Considered subjects changing antidepressant class and those who stopped and restarted antidepressant use at a later study visit. Model adjusted for age, sex, race/center, education, BMI, cigarette smoking, alcohol use, antihypertensive medications, diabetes mellitus, and the year of diagnosis. (HDL, LDL, statins use for MI and stroke model). AF indicates atrial fibrillation; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CVD, cardiovascular disease; HDL, high‐density lipoprotein; HF, heart failure; HR, hazard ratio; LDL, low‐density lipoprotein; MI, myocardial infarction; SSRI, selective serotonin reuptake inhibitor.
HR for each outcome comparing use of SSRIs to non‐SSRIs.