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. 2019 Jun 14;11:5501–5511. doi: 10.2147/CMAR.S200716

Figure 4.

Figure 4

AKT and ERK signalling pathways are associated with MAT2B knockdown in TNBC cells. (A) MDA-MB-231 cells were treated with control shRNA, MAT2B shRNA, U0126, or MK2206, then harvested for western blots analyses. The data are from densitometric experiments illustrating P-AKT, AKT, P-ERK, and ERK protein expression in cells. (B) Cells were treated with control shRNA, MAT2B shRNA, U0126, or MK2206, then subjected to cell proliferation analyses. (C) Cells were treated with control shRNA, MAT2B shRNA, U0126, or MK2206, then subjected to a colony formation assay. (D) Cells were treated with control shRNA, MAT2B shRNA, U0126, or MK2206, then subjected to a wound-healing assay. (E, F) Cells were treated with control shRNA, MAT2B, shRNA, U0126, or MK2206, then subjected to TUNEL and caspase-3 activity assays. *p<0.05, **p<0.01.