Table 3.
Survival rate of mice infected with clinical strains of methicillin-resistant S. aureus and colistin-resistant A. baumannii treated with piscidin-1 and its analogs 15 min after infection
| Treatment | Survived rate (%) of mice infected with clinical strain of methicillin-resistant S. aureus (MRSA) | Survived rate (%) of mice infected with clinical strain of colistin-resistant A. baumannii |
|---|---|---|
| Piscidin-1 | 73.3±14.4 | 78.3±14.21 |
| I16K-piscidin-1 | 93.3±13.5 | 100 |
| I9K-piscidin-1 | 80±26.6 | 86.6±16.4 |
| I9A-piscidin-1 | 66.6±34.8 | 73.3±28.2 |
| I16A-piscidin-1 | 73.3±22.5 | 73.3±38.6 |
| PBS (control) | 0 | 0 |
Notes: Survival rate is related to 168 h after the treatment. The survival rate of mice treated with I16K-piscidin-1 after infection with clinical strains of A. baumannii or MRSA was significantly higher than those treated with the parent peptide (piscidin-1) (p<0.05). Data are presented as mean±SD.
Abbreviations: A. baumannii; Acinetobacter baumannii; S. aureus, Staphylococcus aureus.