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Grading of toxicity in mice (n =7 per group) intramuscularly injected with piscidin-1 and its analogs
| Dose (mg/mouse) | Toxicity grades | ||||
|---|---|---|---|---|---|
| Piscidin-1 | I16K-piscidin-1 | I9K-piscidin-1 | I9A-piscidin-1 | I16A-piscidin-1 | |
| 0.5 | NT | NT | NT | NT | NT |
| 1 | NT | NT | NT | NT | NT |
| 2 | 1: NT 3: level 1 3: level 2 |
NT | 2: NT 3: level 1 2: level 2 |
1: NT 3: level 1 3: level 2 |
2: NT 2: level 1 3: level 2 |
Notes: Toxicity grades: level 1, narrowing of eyes; level 2, crouching and huddling.
Abbreviation: NT, no toxicity.
