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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: ACS Infect Dis. 2018 Jan 17;4(4):577–591. doi: 10.1021/acsinfecdis.7b00212

Table 3.

Biological assay data for cross-over series against P. falciparum and HepG2 cells.

graphic file with name nihms-1032843-t0038.jpg
ID R1 R2 P. fal. D6 EC50 (μM)a HepG2 TC50 (μM)b,c,d SI cLogP LLE
40 A graphic file with name nihms-1032843-t0039.jpg 0.026 >4 >150 2.1 5.5
41 B 0.035 >3 >86 4.4 3.1
42 C 0.093 21 230 3.1 3.8
43 A graphic file with name nihms-1032843-t0040.jpg 0.94 4.5 4.8 1.6 4.4
44 B 0.25 23 92 3.9 2.6
45 A graphic file with name nihms-1032843-t0041.jpg 0.13 17 540 3.1 3.8
46 A graphic file with name nihms-1032843-t0042.jpg 0.054 22 410 2.4 4.8
47 B 0.099 7.6 77 4.7 2.2
48 A graphic file with name nihms-1032843-t0043.jpg 0.18 21 120 2.5 4.3
49 B 0.078 4.7 60 4.7 2.3
Chloroquine 0.0050 3.3 660
a

All r2 values >0.9

b

n = 1 biological replicate made up of 2 technical replicates

c

concentration which is toxic to 50% of the cell population

d

tested concentration ranges were determined based on compound solubility