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. 2019 Jun 13;9:499. doi: 10.3389/fonc.2019.00499

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Copyright © 2019 Khan, Ullah, Siddique, Liu, Ullah, Xue, Yang and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cytotoxicity analysis of human osteosarcoma cell line (MNNG/HOS) against Se-HAp and its modification with different concentrations of catechins, i.e., 5% (CC/Se-HAp1), 7% (CC/Se-HAp2), and 10% (CC/Se-HAp3) relative to control. (B) Viability analysis of human bone marrow stem cells (hBMSCs) on Se-HAp and its modification with 5% catechins (i.e., CC/Se-HAp1) and 10% catechins (i.e., CC/Se-HAp3) relative to control. (C) ROS inhibitor attenuated the cytotoxic effect of nanoparticles, which resulted in higher cell viability. ^*p < 0.01, ^**p < 0.001, ^***p < 0.0001 indicate significant differences of CC/Se-HAp-3 in comparison with Se-HAp.