Table 1. Adipose phenotypes of clock disruption in mice.

Mouse/Mutation/Experiment	Phenotype	Reference
Light exposure at night	Metabolic and behavioral phase shifts, weight gain	[13,78]
Mistimed food intake	Tissue clock phase shifts, weight gain	[30,31]
High-fat diet ad libitum	Blunted behavioral and tissue clock rhythms, weight gain, hyperphagy	[34]
Chronic jet lag (6h advance/week)	Weight gain	[37]
Constant light exposure	Weight gain	[101]
SCN lesion	Loss of behavioral and molecular rhythms, obesity, hyperphagy	[102]
Clock mutation	Blunted behavioral rhythms, weight gain, hyperphagy	[60]
Bmal1 KO	Lean, hyperlipidemia	[61]
Per1/2 double KO	Leptin resistance	[103]
Per2 KO	Altered lipid metabolism, hypotriglyceridemia, weight gain under HFD	[104,105]
Per3 KO	Increased fat mass	[106]
Cry1 KO	Resistant to diet induced obesity through HFD (not Cry2 KO)	[107]
Cry1/2 double KO	Loss of behavioral rhythms, hyperinsulinemia, weight gain	[108-110]
Reverbα/β double KO	Loss of behavioral rhythms, hyperlipidemia, hyperglycemia, hepatic steatosis	[111-113]
Liver Bmal1 KO	Hypoglycemia during fasting period	[62]
Pancreas Bmal1 KO	Hypoinsulinemia	[63]
Adipose tissue Bmal1 KO	Weight gain	[65]
Muscle Bmal1 KO	Weight gain	[64]