Table 1. Some key papers using different in vivo approaches to measure internal desynchrony of circadian gene expression.

In Vivo method
Citation	Animal Model	Detection Method
Saini et al., 2013 [29]	Viral delivered Adv-Bmal1-luc or RevErba-luc; PER2::LUC mice	CCD camera, or PMT
Ono et al, 2017 [28]	Per1-luc, Bmal1-Eluc mice	Implanted optical fiber connected to a PMT
Hamada et al., 2016 [26]	Per1-luc, Bmal1-Eluc mice	2 CCD cameras with scintillators used for quantification of signal from multiple sites
Mei et al., 2018 [27]	Injection of Per1 and Cry1 transcription reporter virus Venus fluorophore	Implanted optical fiber delivering excitation light and connected to a PMT

PMT - Photomultiplier Tube

CCD - Charge-coupled device