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Human circadian physiology. A variety of human physiologic processes are under circadian control. Peak times of different processes and clock outputs are shown as colored circles. Highlighted with red arrows are the peak times of Plasminogen Activator Inhibitor-1 (PAI-1) and markers of Platelet Activation. Note there is an increased frequency of stroke onset between 6 AM and 12 PM as indicated by the shaded red bar.
