Figure 2.
Res attenuates apoptosis and oxidative stress in prefrontal cortex 48 hours after SAH.
(A) TUNEL-positive cells: SAH increased TUNEL-positive cells (green). Res treatment markedly decreased apoptotic cells. Scale bars: 50 μm. (B) ROS and MDA content: Res treatment noticeably decreased ROS and MDA content. Data are expressed as the mean ± SD (n = 8). **P < 0.01, ***P < 0.001, vs. sham group; #P < 0.05, ##P < 0.01, vs. SAH group (one-way analysis of variance followed by post hoc Tukey’s test). Res: Resveratrol; SAH: subarachnoid hemorrhage; TUNEL: terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick-end labeling; ROS: reactive oxygen species; MDA: malondialdehyde.