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. 2019 Oct;14(10):1713–1714. doi: 10.4103/1673-5374.257523

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Copyright: © Neural Regeneration Research

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LRRK2 kinase activity regulates PKA-NFκB p50 inhibitory pathway.

Microglial cells with LRRK2-G2019S exhibit increased LRRK2-RIIβ interaction and RIIβ phosphorylation state and a reduction of PKA-mediated NFκB p50 phosphorylation level, indicative of an inhibition state of PKA. Whereas, microglia cells with LRRK2 pharmacological inhibition (GSK) exhibit reduced LRRK2-RIIβ interaction and RIIβ phosphorylation state, increased cAMP and PKA-mediated NFκB p50 phosphorylation levels, all indicative of an activation state of PKA. LRRK2: Leucine-rich repeat kinase; PKA: protein kinase A; NFκB: nuclear factor kappa B.