Table 2.
Summary of age and genotype effects over all drugs classified according to the 16 polymorphic genes in drug transport and biotransformation
| Gene | Gene effect | Age effect | ||||
|---|---|---|---|---|---|---|
| Mean | Min | Max | Mean | Min | Max | |
| BCRP | 2.82 | 2.64 | 3 | 0.95 | 0.65 | 1.32 |
| CYP1A2 | 0.65 | 0.65 | 0.65 | 1.15 | 0.99 | 1.31 |
| CYP2B6 | 2.13 | 1.46 | 3.11 | 1.15 | 1.05 | 1.25 |
| CYP2C19 | 3.05 | 0.73 | 8.83 | 1.54 | 0.92 | 2.63 |
| CYP2C8 | 1.14 | 1.14 | 1.14 | |||
| CYP2C9 | 2.25 | 0.99 | 5.45 | 1.11 | 0.64 | 1.49 |
| CYP2D6 | 2.90 | 0.05 | 10 | 1.62 | 0.64 | 3.82 |
| CYP3A4 | 1.50 | 1.43 | 1.56 | 1.61 | 1.32 | 2.18 |
| CYP3A5 | 2.30 | 2.10 | 2.49 | 1.26 | 0.88 | 1.64 |
| DPD | 10 | 10 | 10 | 2.30 | 1.12 | 3.48 |
| MDR1 | 1.24 | 1.10 | 1.38 | 1.69 | 1.06 | 2.37 |
| NAT2 | 2.37 | 2.25 | 2.49 | 1.38 | 1.22 | 1.55 |
| OAT1, OAT3 | 1.41 | 1.33 | 1.47 | |||
| OATP1B1 | 2.16 | 1.5 | 2.90 | 1.32 | 0.87 | 1.63 |
| OCT1 | 2.21 | 1.70 | 3 | 1.49 | 1.42 | 1.57 |
| TPMT | 9.55 | 2.09 | 17 | |||
| UGT1A1 | 1.39 | 1.03 | 1.77 | 1.29 | 0.86 | 2.11 |
| UGT2B15 | 1.90 | 1.72 | 2.08 | 1.38 | 1.29 | 1.48 |