Figure 1.

Review outline. This review highlights the impact of changes in autophagy within cancer cells, as well as in the context of the complex cancer microenvironment. Part I describes how aberrant autophagy can contribute to cancer initiation and maintenance as well as therapy resistance (pp. 6‐16). Part II describes the role of autophagy in different stromal cells within the tumor microenvironment, such as fibroblasts and mesenchymal stem cells (pp. 16‐18). Further, the impact of autophagy on anticancer immune responses is described (pp. 18‐27). Blue, 4′,6‐diamidino‐2‐phenylindole (DAPI) staining; green, fibronectin staining for stroma; red, CD8 staining for cytotoxic T‐cell [Color figure can be viewed at wileyonlinelibrary.com]