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. 2018 Oct 4;59(1):7–19. doi: 10.1002/jcph.1313

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© 2018, The Authors. The Journal of Clinical Pharmacology published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Mean (± SD) clobazam (A) and N‐desmethylclobazam (B) plasma concentrations following a single oral dose of 20‐mg clobazam suspension (test) or tablet (reference).³² In this randomized, open‐label, 2‐way crossover study, participants received a single dose of 20‐mg CLB oral suspension or tablet on study day 1 and day 15, with an intervening 14‐day washout period. PK parameters were measured from blood samples drawn predose (0 hours) and regularly through 312 hours after dose, quantified via LC‐MS/MS. The panels on the left show the entire time course; the panels on the right show finer detail for the plasma concentrations versus time in the first 24 hours. CLB, clobazam; LC, liquid chromatography; MS, mass spectrometry.