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. 2018 Oct 4;59(1):7–19. doi: 10.1002/jcph.1313

Figure 3.

Figure 3

Hepatic function status and apparent clearance rate of CLB (A, B) and N‐CLB (C, D). Note: K40 is equivalent to the clearance rate of N‐CLB because the apparent volume of N‐CLB was fixed at 1 L. CL, clearance; CLB, clobazam; N‐CLB, N‐desmethylclobazam. Reproduced from Tolbert D, Bekersky I, Chu HM, Ette EI. An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics. J Clin Pharmacol. 2016;56(2):213‐222, with permission conveyed through Copyright Clearance Center, Inc.