Table 2.
No. | Sex | Reason for HSCT | Donor | HLA mismatch | Cause of ESRD | Age (y) | IS after RT | IS‐free (y) | |
---|---|---|---|---|---|---|---|---|---|
At RT | Donor | ||||||||
1 | M | Wiskott‐Aldrich Syndrome | Mother | Two mismatches | Mesangial proliferative GN | 18 | 42 | Glucocorticoids, CyA | 24 |
2 | F | ALL | Brother | HLA‐identical | HUS | 28 | 25 | None, later AZA and Glucocorticoids | 0 |
3 | F | Aplastic anemia | Father | Three mismatches | Radiation nephritis | 14 | NK | Glucocorticoids, CyA | 21 |
4 | F | CML | Sister | Two mismatches | BMT‐NP | 37 | 35 | None | 19 |
5 | F | AML | Brother | HLA‐identical | HUS | 40 | NK | Glucocorticoids and AZA | NK |
6 | M | AML | Sister | HLA‐identical | BMT‐NP | 39 | 33 | None | 10 |
7 | M | Morbus Hodgkin | Brother | HLA‐identical | BMT‐NP | 48 | 51 | None | 4 |
8 | F | AML | Unrelated | HLA‐identical | BMT‐NP | 29 | NK | None | 9 |
9 | F | CML | Sister | HLA‐identical | Diabetes type 1 | 37 | NK | None | 17 |
10 | M | CML | Sister | HLA‐identical | Unknown | 64 | 56 | None | 11 |
11 | M | Lymphoma | Sibling | HLA‐identical | HUS/TTP | 59 | 67 | MMF, Glucocorticoids | 5 |
12 | F | ALL | Mother | One mismatch | BMT‐NP | 30 | 57 | MMF, Glucocorticoids | 5 |
13 | M | AML | Father | Two mismatches | CNI‐associated | 21 | 45 | Tac, MMF, Glucocorticoids | 9 |
14 | M | AML | Sister | HLA‐identical | TTP | 28 | 26 | Tac, MMF | 3 |
15 | F | Comb. immune‐deficiency syndrome | Mother | Three mismatches | Loss of first renal allograft due to infection | 22 | 61 | CyA, Glucocorticoids | 6 |
16 | M | Idiopathic aplastic anemia | Sister | HLA‐identical | Chronic nephangiosclerosis | 41 | 52 | Glucocorticoids | 9 |
17 | F | AML | Unrelated | HLA‐identical | Complication of aGvHD treatment | 17 | 46 | Tac, Glucocorticoids | 9 |
18 | M | Polymorphic rhabdomyosarkoma | Father | Two mismatches | BMT‐NP | 21 | 43 | Glucocorticoids | 3 |
19 | M | ALL | Father | Three mismatches | BMT‐NP | 25 | 46 | Glucocorticoids | 1 |
20 | M | B‐cell non‐Hodgkin lymphoma | Sister | HLA‐identical | Acute and chronic rejection of 1. transplant kidney | 30 | 22 | Glucocorticoids | 13 |
21 | M | Aplastic anemia | Sister | HLA‐identical | CNI toxicity | 54 | 63 | Single Dose Glucocorticoid | 1,5 |
22 | F | Sickle cell disease | Mother | Three mismatches | Focal segmental glomerulosclerosis due to SCD | 28 | 56 | Glucocorticoid, MMF, Tacrolimus | 0,2 |
By some authors the cause of ESRD was described as bone marrow transplant nephropathy (BMT‐NP). In the literature BMT‐NP is defined as chronic renal disease presenting within 100 days after BMT. It includes chemo‐irradiation–associated nephropathies caused by the conditioning therapies in the absences of other nephrotoxins.14, 40