Table 3.
Pooled analysis of blood glucose profiles and excursion for East Asian and Caucasian injection‐naive patients with inadequate glycemic control after oral antihyperglycemic medication
| Time Point | Unadjusted Preprandial BGa, mmol/L | Adjusted Preprandial BGb, mmol/L | Unadjusted Postprandial BGa, mmol/L | Adjusted Postprandial BGb, mmol/L | Unadjusted BG Excursiona, mmol/L | Adjusted BG Excursionb, mmol/L | |||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SD) | LS mean (SE) | N | Mean (SD) | LS mean (SE) | N | Mean (SD) | LS mean (SE) | |
| Morning | |||||||||
| Caucasian | 3791 | 9.92 (2.806) | 9.76 (0.035) | 3733 | 12.49 (3.689) | 12.32 (0.051) | 3728 | 2.60 (2.495) | 2.59 (0.045) |
| East Asian | 1430 | 9.20 (2.228) | 9.61 (0.060) | 1432 | 13.22 (3.390) | 13.63 (0.085) | 1430 | 4.02 (2.757) | 4.03 (0.075) |
| P valuec | <0.001 | 0.048 | <0.001 | <0.001 | <0.001 | <0.001 | |||
| Midday | |||||||||
| Caucasian | 3524 | 9.95 (3.435) | 9.82 (0.047) | 3490 | 11.36 (3.480) | 11.23 (0.051) | 3473 | 1.44 (2.449) | 1.43 (0.049) |
| East Asian | 1426 | 9.48 (3.059) | 9.82 (0.078) | 1425 | 12.97 (3.392) | 13.19 (0.082) | 1425 | 3.48 (3.006) | 3.37 (0.080) |
| P valuec | <0.001 | 0.960 | <0.001 | <0.001 | <0.001 | <0.001 | |||
| Evening | |||||||||
| Caucasian | 3766 | 10.02 (3.345) | 9.88 (0.046) | 3742 | 11.77 (3.501) | 11.60 (0.049) | 3729 | 1.78 (2.408) | 1.74 (0.047) |
| East Asian | 1426 | 9.53 (3.150) | 9.85 (0.078) | 1419 | 12.65 (3.493) | 12.97 (0.083) | 1417 | 3.14 (3.112) | 3.16 (0.080) |
| P valuec | <0.001 | 0.767 | <0.001 | <0.001 | <0.001 | <0.001 | |||
| Daily | |||||||||
| Caucasian | 3747 | 9.98 (2.877) | 9.82 (0.034) | 3699 | 11.90 (3.220) | 11.74 (0.040) | 3684 | 1.96 (1.524) | 1.95 (0.028) |
| East Asian | 1427 | 9.41 (2.431) | 9.80 (0.058) | 1425 | 12.95 (2.923) | 13.28 (0.068) | 1424 | 3.55 (1.791) | 3.51 (0.048) |
| P valuec | <0.001 | 0.727 | <0.001 | <0.001 | <0.001 | <0.001 |
Abbreviations: BG, blood glucose; HbA1c, glycated haemoglobin; LS least‐squares; SD, standard deviation; SE, standard error of the mean.
a
ANCOVA with race as a fixed effect.
b
Adjusted for baseline body weight, age, duration of type 2 diabetes mellitus, and baseline HbA1c.
c
Differences between East Asian and Caucasian groups.