Table 2.

Results of fluorescein staining scores (NEI scale), at baseline, month 1 and end of study period (≥3 months). N = 51

Corneal area	Visit	Score	Change in scores			Clearing
		Mean ± SD	Mean ± SD	95%CI	P value	N	n (%)
A: Central	Baseline	0.7 ± 0.8	–	–	–	30	4 (13.3)
	Month 1	0.3 ± 0.7	−0.4 ± 0.8	–	0.003	30	19 (63.3)
	End of study period	0.2 ± 0.4	−0.5 ± 0.8	(−0.7,‐0.2)	<0.001	30	19 (63.3)
B: Superior	Baseline	0.8 ± 1.1	–	–	–	33	8 (24.2)
	Month 1	0.3 ± 0.8	−0.5 ± 1.3	–	0.010	33	23 (69.7)
	End of study period	0.3 ± 0.6	−0.5 ± 1.1	(−0.8,‐0.2)	0.001	33	22 (66.7)
C: Temporal	Baseline	1.3 ± 0.9	–	–	–	48	6 (12.5)
	Month 1	0.4 ± 0.5	−0.9 ± 0.9	–	<0.001	48	30 (62.5)
	End of study period	0.6 ± 0.7	−0.7 ± 1.0	(−1.0,‐0.4)	<0.001	48	21 (43.8)
D: Nasal	Baseline	1.6 ± 0.9	–	–	–	50	4 (8.0)
	Month 1	0.7 ± 0.7	−0.9 ± 1.0	–	<0.001	50	23 (46.0)
	End of study period	0.8 ± 0.8	−0.8 ± 1.3	(−1.1,‐0.4)	<0.001	50	19 (38.0)
E: Inferior	Baseline	2.6 ± 0.9	–	–	–	51	0 (0.0)
	Month 1	1.5 ± 1.0	−1.1 ± 1.2	–	<0.001	51	5 (9.8)
	End of study period	1.4 ± 1.0	−1.2 ± 1.2	(−1.5,‐0.8)	<0.001	51	6 (11.8)
Total (entire corneal area)	Baseline	6.9 ± 3.1	–	–	–	51	0 (0.0)
	Month 1	3.2 ± 2.5	−3.8 ± 3.3	–	<0.001	51	3 (5.9)
	End of study period	3.3 ± 2.7	−3.6 ± 3.2	(−4.5,−2.7)	<0.001	51	6 (11.8)