Table 2. The diagnostic value of miR-421 and tumor markers for GC.
| Cut-off | Sensitivity(%) | Specificity(%) | FPR(%) | FNR(%) | Accuracy(%) | Youden index (%) | AUC | p | |
|---|---|---|---|---|---|---|---|---|---|
| miR-421 | 3.23 | 96.67 | 95.56 | 4.44 | 3.33 | 96.30 | 92.22 | 0.981(0.942–0.997) | <0.0001 |
| CEA | 1.94 | 67.06 | 66.67 | 33.33 | 32.94 | 66.93 | 33.73 | 0.672(0.584–0.752) | 0.0002 |
| CA125 | 18.75 | 45.59 | 100.00 | 0 | 54.41 | 67.26 | 45.59 | 0.645(0.549–0.732) | 0.0055 |
| CA153 | 11.31 | 68.66 | 62.22 | 37.78 | 31.34 | 66.07 | 30.88 | 0.656(0.561–0.743) | 0.0034 |
| CA211 | 2.2 | 80.65 | 95.65 | 4.35 | 19.35 | 86.96 | 76.30 | 0.799(0.711–0.871) | <0.0001 |
| CA50 | 7.96 | 55.84 | 85.29 | 14.71 | 44.16 | 64.86 | 41.14 | 0.754(0.663–0.831) | <0.0001 |
Notes.
- AUC
- Area under the curve
- FPR
- False positive rate
- FNR
- False negative rate
Positive was defined as > cut-off value; Negative was defined as < cut-off value; The sensitivity, specificity, FPR, FNR, accuracy and Youden index were calculated based on the number of positive cases and negative cases.