Table 4. The diagnostic value of miR-421 and tumor markers for Pre.

	Cut-off	Sensitivity(%)	Specificity(%)	FPR(%)	FNR(%)	Accuracy(%)	Youdenindex (%)	AUC	p
miR-421	3.23	66.29	95.56	4.44	33.71	76.37	61.85	0.872 (0.804–0.924)	<0.0001
CA153	11.81	72.00	60.00	40.00	28.00	66.32	32.00	0.679 (0.576–0.772)	0.0012
CA211	2.2	85.00	95.56	4.44	15.00	90.56	80.56	0.844 (0.750–0.914)	<0.0001
CA50	7.26	52.08	82.35	17.65	47.92	64.63	34.44	0.677 (0.564–0.776)	0.0034

Notes.

The sensitivity, specificity, FPR, FNR, accuracy and Youden index were calculated based on the number of positive cases and negative cases. AUC, FPR and FNR, Positive and Negative as stated in Table 2.