Table 3. The percentages of individual bile acid relative to TBA in ESRD and healthy control group (%).
| Metabolite | ESRD (N = 77) | HC (N = 30) | Z-value | P-value |
|---|---|---|---|---|
| CA | 1.32 (0.71–2.82) | 2.43 (1.06–6.56) | 2.927 | 0.003 |
| CDCA | 3.86 (1.88–8.10) | 14.76 (6.49–22.74) | 5.049 | <0.001 |
| DCA | 1.37 (0.21–4.37) | 6.50 (1.39–17.28) | 3.544 | <0.001 |
| HDCA | 0.13 (0.05–0.38) | 0.51 (0.08–1.72) | 2.592 | 0.010 |
| LCA | 0.10 (0.02–0.25) | 0.26 (0.00–0.64) | 1.865 | 0.062 |
| UDCA | 0.48 (0.17–1.06) | 1.17 (0.71–1.89) | 3.024 | 0.002 |
| α+ωMCA | 0.10 (0.03–0.29) | 0.39 (0.13–0.93) | 2.871 | 0.004 |
| βMCA | 0.05 (0.00–0.17) | 0.00 (0.00–0.00) | −3.700 | <0.001 |
| γMCA | 0.48 (0.15–1.05) | 0.93 (0.50–2.23) | 3.329 | 0.001 |
| 7KLCA | 0.22 (0.12–0.48) | 0.48 (0.28–0.70) | 3.440 | 0.001 |
| 12KLCA | 0.07 (0.00–0.22) | 0.36 (0.00–1.03) | 2.646 | 0.008 |
| 6,7-diketoLCA | 0.08 (0.00–0.22) | 0.23 (0.04–0.40) | 2.330 | 0.020 |
| GCA | 11.06 (8.22–14.88) | 6.13 (4.04–8.76) | −4.383 | <0.001 |
| GCDCA | 41.62 (33.90–48.88) | 30.44 (25.60–38.81) | −4.016 | <0.001 |
| GDCA | 2.59 (0.20–8.16) | 5.53 (0.97–11.10) | 1.298 | 0.194 |
| GHCA | 0.52 (0.32–0.90) | 0.48 (0.35–0.76) | −0.194 | 0.846 |
| GLCA | 0.02 (0.00–0.20) | 0.09 (0.00–0.26) | 0.813 | 0.416 |
| GUDCA | 8.79 (4.93–13.32) | 6.67 (2.76–11.00) | −1.345 | 0.178 |
| TCA | 2.52 (1.66–3.77) | 1.13 (0.61–1.57) | −5.229 | <0.001 |
| TCDCA | 5.33 (3.69–9.71) | 2.56 (1.79–3.88) | −4.834 | <0.001 |
| TDCA | 0.67 (0.09–1.68) | 0.74 (0.16–1.44) | 0.097 | 0.922 |
| THCA | 0.13 (0.08–0.26) | 0.11 (0.06–0.15) | −2.057 | 0.040 |
| TαMCA | 0.10 (0.06–0.16) | 0.05 (0.00–0.07) | −4.483 | <0.001 |
| TβMCA | 0.45 (0.27–0.71) | 0.42 (0.24–0.67) | −0.388 | 0.698 |
| TUDCA | 0.63 (0.36–1.41) | 0.33 (0.24–0.67) | −3.593 | <0.001 |
| UnconBA | 12.22 (6.77–20.86) | 35.65 (22.65–52.91) | 6.124 | <0.001 |
| TaurineBA | 11.38 (8.05–17.91) | 5.78 (4.21–8.42) | −4.459 | <0.001 |
| GlycineBA | 71.15 (65.22–80.59) | 54.54 (42.78–66.70) | −4.862 | <0.001 |
| ConBA | 87.78 (79.14–93.23) | 64.35 (47.09–77.35) | −6.124 | <0.001 |
| PBA | 74.95 (65.37–83.39) | 65.49 (54.34–74.97) | −3.274 | 0.001 |
| SBA | 20.43 (12.13–29.42) | 26.20 (17.70–36.79) | 2.303 | 0.021 |
| PBA/SBA | 3.63 (2.15–7.09) | 2.65 (1.44–4.40) | −2.538 | 0.011 |
| UnconBA/ConBA | 0.14 (0.07–0.26) | 0.55 (0.29–1.13) | 6.124 | <0.001 |
Notes:
Data presented as median and inter-quartile range (IQR).
Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; UDCA, ursodeoxycholic acid; α+ωMCA, α-muricholic acid and ω-muricholic acid; βMCA, β-muricholic acid; γMCA, γ-murocholic acid; 7KLCA, 7-ketolithocholic acid; 12KLCA, 12-ketolithocholic acid; 6,7-diketoLCA, 6,7-diketolithocholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GHCA, glycohyocholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; THCA, taurohyocholic acid; TαMCA, tauro α-muricholic acid; TβMCA, tauro β-muricholic acid; TUDCA, tauroursodeoxycholic acid; UnconBA, unconjugated bile acid; ConBA, conjugated bile acid; PBA, primary bile acid; SBA, secondary bile acid. TaurineBA, taurine conjugated bile acid; GlycineBA, glycine conjugated bile acid.