Figure 3. LBP treatment protects the septic kidney injury by activating the antioxidant responses through Keap 1- Nrf2∕ARE signaling pathway. (A) Effect of LBP on the antioxidant response in LPS induced septic kidney. (B) Effect of LBP on the Keap 1- Nrf2∕ARE signaling pathway related genes. (C) Western blot analysis of antioxidant responses and Keap 1- Nrf2∕ARE signaling pathway related proteins. (D) Quantitative analysis of the Western blot results. **, P<0.01, versus the control group; ##, P<0.01, versus the LPS group. Normal control group (Con): normal feeding; LPS model group (LPS): intraperitoneal injection with LPS (5 mg/kg); Ulinastatin group (ULI): intravenous injection with Ulinastatin (10000 U/kg); LBP-1 group: giving intragastric administration with 200 mg/kg LBP 1h after LPS injection; LBP-2 group: giving intragastric administration with 400 mg/kg LBP 1h after LPS injection; LBP-3 group: giving intragastric administration with 800 mg/kg LBP 1h after LPS injection.