Figure 6. Nrf2 inhibition by brusatol reverses the protective effect of LBP on the LPS induced septic kidney injury. (A-E) Influence of brusatol on the expressions of immune factors in sepsis induced rat kidney. (F) Pathological morphology observation and scoring of kidney tissue among groups. **, P<0.01, versus the DMSO group; ##, P<0.01, versus the LPS group; ΔΔ, P<0.01, versus the LBP group. DMSO control group (DMSO): intraperitoneal injection with DMSO. LPS model group (LPS): intraperitoneal injection with LPS (5 mg/kg); LBP-3 group: giving intragastric administration with 800 mg/kg LBP 1h after LPS injection; Brusatol group: intraperitoneal injection with LPS together with 2 mg/kg of brusatol, then LBP was administrated 1h after.