Figure 3. Effects and mechanisms of propofol on the PI3K/Akt pathway in II/R-injured intestines and lungs. (A) Representative Western blot showing the expression of caspase-3 and phosphorylation of Akt in intestinal tissues. (B) Representative Western blot showing the expression of caspase-3 and phosphorylation of Akt in lung tissues. Both in intestinal and lung tissues, the level of caspase-3 in the P group was significantly decreased compare to the II/R group. The level of caspase-3 in the W group was increased significantly compare to the P group. Moreover, we found that compare with the II/R group, the expressions of p-Akt were markedly increased in the P group; compare with the P group, the expressions of p-Akt were significantly decreased in the W group. Data are expressed as mean ± standard deviation (n=6). *P<0.05 vs. Sham group. ^# P<0.05 vs. II/R group. ^★ P <0.05 vs. P group.