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. 2018 Sep 26;107(1):114–121. doi: 10.1002/jbm.a.36538

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© 2018 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The functionalization of alginate hydrogels (ALG) with tyramine (TYR) using the carbodiimide chemistry (EDC, NHS) was confirmed by the structural elucidation via ¹H NMR spectroscopy. Besides the typical homo‐ and heteropolymeric block fractions of alginates consisting of mannuronate and guluronate, the aromatic protons of the introduced tyramines phenolic group (6.88–7.23 ppm) were present within the tyramine‐alginate (ALGTYR) spectra. Without using EDC/NHS, tyramine did not bind to ALG excluding an unspecific reaction (ALG + TYR (−EDC/NHS)).