TABLE II.

Patient Characteristics and Association with Overall Survival.

Variable	Pooled over multiply imputed dataa				Complete case
	Univariate		Multivariable		Univariate		Multivariable
	HR (95% CI)	P	aHR (95% CI)	P	HR (95% CI)	P-value	aHR (95% CI)	P
Male	1.08 (0.66–1.75)	0.76			1.08 (0.66–1.75)	0.76
Age (in decades)	1.30 (1.15–1.45)	<0.001	1.26 (1.11–1.42)	0.000	1.30 (1.15–1.45)	<0.001	1.31 (1.07–1.61)	0.01
Race	R2=0.014	P=0.62			R2=0.014	P=0.62
Caucasian	1	Reference			1	Reference
African American	0.77 (0.45–1.31)	0.33			0.77 (0.45–1.31)	0.33
Hispanic	1.29 (0.78–2.14)	0.32			1.29 (0.78–2.14)	0.32
Native American/Alaskan	1.98 (0.27–14.23)	0.50			1.98 (0.27–14.23)	0.50
Asian	0.81 (0.26–2.57)	0.73			0.81 (0.26–2.57)	0.73
Cardiac allograft versus all others	1.63 (1.02–2.61)	0.04	1.42 (0.81–0.48)	0.21	1.63 (1.02–2.61)	0.04	NAb
Prior PTLD	1.11 (0.56–2.22)	0.77			1.11 (0.56–2.22)	0.77
Years to PTLD	1.04 (0.99–1.09)	0.12			1.04 (0.99–1.09)	0.12
Nodal	0.85 (0.50–1.45)	0.56			0.85 (0.50–1.45)	0.56
Extranodal	1.05 (0.69–1.61)	0.82			1.05 (0.69–1.61)	0.82
HBV at SOTa	1.10 (0.32–3.74)	0.87			1.43 (0.20–10.3)	0.73
HCV at SOTa	1.20 (0.61–2.39)	0.58			1.26 (0.50–3.16)	0.63
Creatinine (per 0.1 mg/dL change)a	1.81 (1.30–2.51)	0.002	1.64 (1.12–2.39)	0.02	1.88 (1.45–2.45)	<0.001	1.54 (1.06–2.22)	0.02
Poor KPS (10–70)a	1.48 (0.77–2.84)	0.23	1.19 (0.68–2.09)	0.54	2.06 (1.0–4.24)	0.05	1.93 (0.72–5.20)	0.19
Year of diagnosis	1.00 (0.93–1.07)	0.90			1.00 (0.93–1.07)	0.90

Multiple imputations were performed using 350 iterations on five data sets.

^aMissing data multiply imputed for HBV, HCV, creatinine, and performance status.

^b36/40 patients with cardiac allografts were missing serum creatinine.

Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; KPS, Karnofsky performance status; PTLD, post-transplant lymphoproliferative disorder.