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(a) Schematic presentation of siRNA/nMOF-Cis synthesis and drug loading. (b) TEM image of siRNA/nMOF-Cis nanoparticles. (c) Confocal microscopy image showing siRNA endosomal escape. (d) Gene silencing efficiency of siRNA/nMOF-Cis expressed as percentage of protein expression. (e) In vitro anticancer efficacy on SKOV-3 cells showing re-sensitization effect with siRNA/nMOF-Cis. Reproduced with permission.[89] Copyright 2014, American Chemical Society.
